Famotidine – Pepcid for Acid Reflux Treatment at Home

Famotidine is a medication that is sold under the brand name Pepcid. Famotidine is used to treat Acid Reflux, GERD and peptic ulcer disease and it can be taken orally or injected into a vein. Famotidine belongs to the group of medicines known as histamine H2-receptor antagonists or H2-blockers. Famotidine – Pepcid works by decreasing the amount of acid production in your stomach.


Is Famotidine available over the counter?

The medicine is available with a doctor’s prescription and also available over the counter however it’s best to consult your doctor before using any medicine.

Indications and dose

Treatment of benign gastric and duodenal ulceration

By mouth
For Adult
40 mg once daily for 4–8 weeks, dose to be taken at night.

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Maintenance treatment of duodenal ulceration

By mouth
For Adult
20 mg once daily, dose to be taken at night.

Reflux oesophagitis

By mouth
For Adult
20–40 mg twice daily for 6–12 weeks; maintenance 20 mg twice daily.



Common or very common

Constipation; diarrhoea; dizziness; fatigue; headache; myalgia; skin reactions


Confusion; depression; erectile dysfunction; gynaecomastia; hallucination; hepatic disorders; leucopenia; nausea; tachycardia

Rare or very rare

Agranulocytosis; alopecia; arthralgia; atrioventricular block; fever; galactorrhoea; pancytopenia; thrombocytopenia; vasculitis



Appetite decreased; dry mouth; taste altered; vomiting

Rare or very rare

Anxiety; chest tightness; drowsiness; insomnia; interstitial pneumonia; libido decreased; muscle cramps; neutropenia; paraesthesia; psychiatric disorder; seizures; severe cutaneous adverse reactions (SCARs)


The manufacturer advises avoiding unless the potential benefit outweighs the risk.


Present in milk—not known to be harmful but manufacturer advises avoiding.

Renal impairment

Seizures are reported very rarely.

Dose adjustments

Use normal dose every 36–48 hours or use half normal dose if eGFR is less than 50 mL/minute/1.73 m2.

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Exceptions to the legal category

Famotidine can be sold to the public for adults and children over 16 years (provided packs do not contain more than 2 weeks’ supply) for the short-term symptomatic relief of heartburn, dyspepsia, and hyperacidity, and for the prevention of these symptoms when associated with consumption of food or drink including when they cause sleep disturbance (max. single dose 10 mg, max. daily dose 20 mg).

Medicinal forms

There can be variations in the licensing of different medicines containing the same drug.

Do NOT use Famotidine with following medicines:

  • Bepridil
  • Cisapride
  • Dronedarone
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using Famotidine with the following medications are not recommended: 

  • Acalabrutinib
  • Amiodarone
  • Amisulpride
  • Amprenavir
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Atazanavir
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Ceritinib
  • Chloroquine
  • Clarithromycin
  • Clofazimine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Dasatinib
  • Degarelix
  • Delamanid
  • Delavirdine
  • Deslorelin
  • Deutetrabenazine
  • Domperidone
  • Donepezil
  • Efavirenz
  • Encorafenib
  • Entrectinib
  • Erlotinib
  • Escitalopram
  • Fexinidazole
  • Fingolimod
  • Fluconazole
  • Fluoxetine
  • Formoterol
  • Fosamprenavir
  • Foscarnet
  • Fostemsavir
  • Gefitinib
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Histrelin
  • Hydroxychloroquine
  • Hydroxyzine
  • Infigratinib
  • Inotuzumab Ozogamicin
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Ledipasvir
  • Lefamulin
  • Lenvatinib
  • Levofloxacin
  • Lofexidine
  • Macimorelin
  • Methadone
  • Metronidazole
  • Mirtazapine
  • Mobocertinib
  • Moxifloxacin
  • Nafarelin
  • Neratinib
  • Octreotide
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pimavanserin
  • Pitolisant
  • Ponesimod
  • Posaconazole
  • Quetiapine
  • Ribociclib
  • Rilpivirine
  • Secretin Human
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Siponimod
  • Solifenacin
  • Sotalol
  • Sotorasib
  • Sulpiride
  • Sunitinib
  • Tacrolimus
  • Tizanidine
  • Tolazoline
  • Trazodone
  • Triclabendazole
  • Triptorelin
  • Vandetanib
  • Vemurafenib
  • Vinflunine
  • Vismodegib
  • Voclosporin
  • Zuclopenthixol

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